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Ingredients
Cacao was domesticated in the upper Amazon, not first in Mesoamerica as long assumed: cacao starch grains, theobromine residues and ancient DNA about 5,300 years ago at the Santa Ana-La Florida site in southeast Ecuador, reported in 2018, are the earliest evidence of its use in the Americas. Mesoamerican peoples, including the Olmec, prepared cacao drinks later, with residues from the Early Formative period, and a genome study found that Criollo cacao was strongly domesticated about 3,600 years ago.